How Does Nitrazepam Work?

By: Annabelle Clarke
May 08, 2021

Nitrazepam, also known as Mogadon, is a derivative of the benzodiazepine class. It is a powerful hypnotic medication that has strong anti-anxiety, sedative, anticonvulsant and myorelaxant properties. This medication improves sleep quality by reducing the amount of time it takes to fall asleep (sleep latency) and increasing the duration of sleep. It also shows promising results in managing myoclonic seizures.

Nitrazepam works by affecting certain parts of the brain known as GABA receptors. It subsequently boosts GABA activity, increasing the level of this naturally-occurring neurochemical in the brain. GABA is involved in the transmission of messages between nerve cells and it helps regulate feelings of nervous tension when nerve cells become overactive.

This neurochemical acts as a natural calming agent, which keeps the brain in balance. This helps with the induction of sleep, reduction of anxiety and relaxation of muscles. Nitrazepam sleeping tablets are therefore beneficial in the short-term treatment of insomnia, especially insomnia associated with anxiety.

The chance of nitrazepam side effects like drowsiness is increased if this medication is taken without going to bed soon after administration. For this reason, this medicine should be taken shortly before going to bed, with or without food. At least seven to eight hours of uninterrupted sleep should be possible so restorative sleep can be achieved. When these basic rules are followed, patients are guaranteed a safe, effective treatment experience.

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How Long Does Nitrazepam Take to Work?

Nitrazepam 10 mg does not cause sudden sleepiness. It takes about thirty to sixty minutes for the medication to become entirely effective. At this stage, an individual will typically fall into a deep, relaxing sleep.

This makes this medication useful in the treatment of sleep onset insomnia. This type of insomnia is characterised by an atypical delay in sleep onset, usually lasting more than 30 to 60 minutes. This tends to significantly reduce total sleep time, resulting in daytime drawbacks like impaired cognition and low mood. This benzodiazepine treatment can help by reducing the time to sleep onset considerably.

This treatment will reach its peak blood concentration levels, which is its maximum effects, in two hours after ingestion. This is when a patient will likely be in slow-wave sleep, which is considered the deepest stage of sleep. The effects will remain for six to eight hours, allowing a patient the chance to benefit from a full night’s sleep.

The durational efficacy of this medication is therefore beneficial for patients with sleep maintenance insomnia. Also known as middle-of-the-night, or MOTN insomnia, this kind of insomnia involves frequent night time awakenings.

MOTN insomnia is highly prevalent and affects about 35% of adults at some stage in their lives. Sleep studies have found that more than 40% of people with this condition find it difficult to resume sleep after waking up during the night. This can significantly increase the likelihood of excessive daytime sleepiness. Thankfully, this benzodiazepine medication can effectively reduce awakenings during the night.

This medication can be taken on consecutive nights to treat help break patterns of poor sleep. However, clinicians often advise that patients take nitrazepam sleeping pills on an intermittent basis to reduce the likelihood of tolerance to the medication. For example, administer a dose 2-3 times a week instead of every night.

How Long Does Nitrazepam Stay in Your System?

On average, the half-life of this medication is 24 hours so it takes about one day for half the medication to be removed from the body. Nitrazepam is an intermediate-acting benzodiazepine. It is generally considered safe with a low risk of daytime drowsiness or rebound insomnia.

This medication has no active metabolites, so it is entirely excreted from the body. The substance can remain in the system for a few days before being completely eliminated. Although this may seem long, this medication does have a shorter half-life than several other sleep aids. The following factors can also affect how long the nitrazepam dosage remains in the body:

  • The amount of medication taken – higher doses will take longer for the body to eliminate.
  • Body mass index (BMI) – patients with a high BMI will take slightly longer to eliminate this medication. An unsteady BMI can impair the function of the liver, further causing the medication to be eliminated at a slower rate.
  • Age of the patient- while younger patients will experience a standard elimination time, older patients tend to eliminate the medication slightly slower because of differing metabolisms.

How Long Do the Effects of Nitrazepam Last?

Once this medication starts working, it stays effective in the body for 6 to 8 hours, which is apt for treating insomnia. A patient who uses this medication is unlikely to experience next-day residual effects like drowsiness. This medication typically allows a person to wake up with sufficient energy levels for the day.

The total amount of sleep time this medication induces generally allows a patient to experience all the stages of restorative sleep. While it is essential to experience all these stages, stage 3 sleep is most beneficial as this stage is responsible for feeling refreshed the following day.

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Does Nitrazepam Help Depression?

Certain chemicals in the brain play an integral role in the development of depressive symptoms. Some of these chemicals are responsible for an increase in nerve cell activity, while others inhibit nerve activity. GABA is one of the inhibitory chemicals and patients with insomnia often have low levels of GABA, making them prone to depression. By increasing GABA, nitrazepam is able to put the brakes on overactive neurons that may result in insomnia and depression.

Insomnia and depression have a close relationship with each other, and both conditions tend to make the other worse. In fact, one of the most common symptoms of depression is the inability to sleep, while severe untreated insomnia may lead to depression.

Since nitrazepam 10 mg has the ability to enhance the actions of GABA, it means that it relieves insomnia, which usually has a positive effect on depressive symptoms. In essence, it indirectly improves the symptoms of depression by relieving sleeping difficulties. This medication can, however, be used with other treatments to treat depression. You can buy nitrazepam in the UK from accredited online pharmacies and benefit from the effects of better sleep such as improved overall mood.

We offer prompt, secure processing of orders and reliable door-to-door shipping of your medication. As well as medication to treat anxiety we also supply a wide range of sleeping pills in the UK and strong painkillers at!

More Product Information:

  • What is Nitrazepam?
  • Nitrazepam Dosage Guide
  • Nitrazepam Side Effects

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